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Through the use of different germoplasmas, the breeders of the Institute has created over the past 40 years more than 35 varieties of soybean, 15 of them over the years included in the State Register. Now in the State Register of Ukraine there are 12 varieties bred in the Institute: Malvina, Podyaka (2012..), Sprytna, Estafeta (2013), Bayika (2014), Kobza (2015), Perlyna (2016). The characteristic of the best varieties is presented. In the NCPGRU, there is formed soybean base collection which includes more than 2680 accessions and is a source of starting material for breeding. There is created and registered in the NCPGRU working collection of soybean for resistance to Fusarium wilt, resistance to heat and drought. The sources of resistance to fusarium, drought resistance, high yield are selected and registered in the NCPGRU. The created collections and selected accessions are recommended for use as a source of starting material in the creation of new soybean varieties resistant to biological and abiotic factors, in scientific and educational programs.